Metal-Ion-Mediated Amyloid-Aggregation in Alzheimer’s Disease: A Mathematical Model of Chelation and Inhibitory Therapies

by Shantia Yarahmadian et al.

We develop a novel, comprehensive, and rigorously validated mathematical framework to investigate the kinetics of amyloid-(A) aggregation in the presence of biologically relevant metal ions, chelating agents, and inhibitor drugs. Building upon and extending existing aggregation models, our approach integrates metal-assisted aggregation, A-assembly, and therapeutic interventions within a unified and mechanistically consistent formulation.