Mathematical Modelling of the Mitochondrial Dicarboxylate Carrier (SLC25A10)
by Ramin Nashebi, Yingying Lyu, Elías Vera-Sigüenza, Daniel A. Tennant & Fabian Spill
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SLC25A10 is a mitochondrial transport protein that exchanges succinate, malate, and phosphate across the inner mitochondrial membrane. We developed a mathematical model of its “ping-pong” transport mechanism and tested it against published measurements from mitochondria and proteoliposomes. The model predicts two transport stages: an early phase in which matrix phosphate supports rapid succinate and malate uptake while phosphate exits, followed by a slower phase dominated by malate–succinate redistribution after phosphate depletion. It also suggests that mitochondrial shape affects transport, with swelling increasing early flux and condensation reducing it. These results help explain how SLC25A10 responds to changing metabolic conditions.
Image Description: Graphical summary of the SLC25A10 mathematical transport model and its biological implications.
