From: "Owens, Roland (NIH/OD) [E]" Sent: Thursday, May 15, 2008 10:21 AM Resent-From: Raymond Mejia Subject: Research Positions at NIH 1) Tenure-Track and Tenure Investigator Positions Systems Immunology and Infectious Disease Modeling, NIAID (deadline: May 23) The National Institute of Allergy and Infectious Diseases (NIAID), Division of Intramural Research (DIR) is seeking several outstanding individuals for its new Program in Systems Immunology and Infectious Disease Modeling (PSIIM). Modern technology allows the analysis of immune responses and host-pathogen interactions at multiple levels --- from intracellular signaling networks, to individual cell behavior, to the functioning of a tissue, organ, and even the whole organism. The challenge is not only to collect the large amounts of data, but also to organize it in a manner that enhances our understanding of how the immune system operates or how pathogens affect their hosts. To do this, it is necessary to develop detailed quantitative models that can be used to predict the behavior of a complex biological system. These models can help explain the mechanisms underlying physiological and pathological responses to infection or vaccination, which can then be employed to design better therapies or vaccines. Achieving these goals requires an interdisciplinary effort and for this reason the PSIIM is organized as an integrated team of scientists and support staff. Within the PSIIM, there will be groups with expertise in the areas of computational biology, bioinformatics, proteomics, genomics, cell biology, immunology, and infectious diseases. These teams will have access to the latest technology for gene expression profiling, high content screening of RNAi libraries for the discovery of pathway components, imaging tools, genomic and proteomic analysis, cores for the genetic manipulation of animals, and a substantial computer infrastructure. They will also have access to BSL3 facilities for working with infectious agents of high priority for human health and biodefense. Although the PSIIM has been established within NIAID and has an immune / infectious disease focus, it is also expected to play a major role in fostering the growth of systems biology efforts throughout the NIH and involving diverse biomedical areas. Current teams in the PSIIM include Immunology, Computational Biology; Modeling and Simulation, and Molecular / Cell Biology; High-throughput screening. The PSIIM is now recruiting for tenure track or tenure level team leader appointments in the following areas: Bioinformatics / Biostatistics: the incumbent will lead a group focused on developing and implementing computational tools and statistical methods for the analysis of genomic and proteomic data. The ideal candidate will have a strong background in statistics, mathematics, programming, and modeling biological systems as well as a strong interest in collaboration with biologists for the elucidation of biological mechanisms. The group will include expertise in software development (C++, Java, Perl, SQL etc.), knowledge of bioinformatic tools, databases and algorithms, and experience with heterogeneous computer environments (UNIX, Windows, Mac). Proteomics: the incumbent will lead a group involved in the development and application of new methods for the etermination of protein number, binding affinities, post-translational modification, and other qualitative and quantitative aspects of protein expression and behavior that are necessary for computer modeling and simulation. Tools such as mass spectrometry and microfluidic-based multiplexed binding assays are expected to be key elements in the efforts of this group. A strong background in protein biochemistry and the relevant instrumentation needed for high-throughput, high-sensitivity analysis is required. Genomics: the incumbent will be responsible for developing novel approaches to the systems-wide analysis of such issues as transcription factor and epigenetic control of gene expression, the effects of allelic polymorphism on gene expression and function, quantitative measurement of gene expression, and the role of non-coding regions and transcripts such as miRNAs in regulating gene/gene product expression patterns. Knowledge of modern methods in high-throughput analysis of gene transcription, transcription factor binding site identification, analysis of epigenetic modifications, and analysis of gene regulatory circuits is required; bioinformatics experience is desirable. These positions and the research activities they conduct are fully funded by the intramural research program of NIAID. Each team leader is expected to build a working group consisting of postdoctoral fellows, students, technicians, and staff scientists. The team leaders will work with the Program Director to help set the goals for the PSIIM and to determine how best to reach these goals as an integrated group. To ensure appropriate career trajectories for those joining the PSIIM team effort, the NIH has modified its tenure policies to take specific account of contributions made in such a team science setting. Applicants should be seeking a difficult challenge in which creativity, technical expertise, and a strong desire to achieve in a team setting will be critical for success. Interested candidates may contact Dr. Ronald Germain, Program Director, PSIIM, DIR, NIAID, at 301-496-1904 or e-mail (rgermain@niaid.nih.gov) for additional information about these positions. To apply, submit your curriculum vitae, bibliography, and a detailed statement of how your expertise can contribute to the success of the PSIIM program, to Wanda Jackson at NIAID.DIR.Search@niaid.nih.gov. In addition, three letters of reference must be sent directly from your three referees to Dr. Robert Hohman, Chair, NIAID Search Committee, c/o Wanda Jackson at NIAID.DIR.Search@niaid.nih.gov or 10 Center Drive, MSC 1356, Building 10, Room 4A22, Bethesda, Maryland 20892-1356. E-mail is preferred. Completed applications MUST be received by Friday, May 23. Please refer to ad #019 for bioinformatics/biostatistics, #020 for proteomics, and #021 for genomics on all correspondence. Further information regarding the DIR laboratories is available at http://www3.niaid.nih.gov/about/organization/dir/default.htm, and information on working at NIAID is available on our website at: http://healthresearch.niaid.nih.gov. ### 2) Tenure-Track Investigator Epidemiologist, Infections & Cancer, NCI (deadline: May 30) The new NCI Infections and Immunoepidemiology Branch (IIB) in the Division of Cancer Epidemiology and Genetics (DCEG) is recruiting for a tenure-track epidemiologist with experience and interest in the study of infectious agents and cancer risk. Research at the IIB focuses on understanding the causes and mechanisms involved in the development of tumors linked to infectious agents and in understanding the mechanisms underlying successful immune responses as they relate to cancer risk and to successful responses to vaccination. Both infectious and host immunological factors are considered in the context of human epidemiological studies. Studies undertaken by the group are often large, international and include rich biological specimen components to permit in-depth evaluation of biological processes, including immunological and inflammatory mechanisms, involved in tumor development using state-of-the-art techniques. The Branch houses the 7,500 woman community-based vaccine trial in Costa Rica designed to evaluate the efficacy and impact of a new HPV-16/18 virus-like particle vaccine and has an active set of studies aimed at evaluating the role of numerous infectious agents (including EBV, HIV, HPV, HTLV-1, and KHSV) and tumor sites (including cervical cancer, gastric cancer, Hodgkin and non-Hodgkin lymphomas, lung cancer, nasopharyngeal carcinoma, and oral/oropharyngeal cancers). Recent efforts have also begun to explore how the microbiome might affect immunity and long-term cancer risk. The successful candidate will receive research support from the intramural research program of NIH for conducting innovative studies aimed at elucidating the role of infectious agents in tumor development. Applicants must have an M.D. and/or Ph.D. in epidemiology or a related field, and considerable post-doctoral experience in cancer epidemiology, viral epidemiology, molecular epidemiology, microbial genomics and/or tumor immunology. A record of peer-reviewed publications in one of these fields is required. The successful candidate should have strong analytical/quantitative skills, a good understanding of biological processes, and a demonstrated ability to collaborate across disciplines. Strong oral and written communication skills are an important requirement. Applications will be evaluated on demonstrated ability to lead complex epidemiologic investigations; to develop a creative, independent program of epidemiological research applicable to understanding infectious determinants of cancer risk; and to collaborate effectively in a multidisciplinary setting. Interested individuals should send a cover letter, curriculum vitae, a brief summary of research experience, accomplishments and research interests and goals, copies of three publications or preprints, and three letters of reference to: Ms. Judy Schwadron; Division of Cancer Epidemiology and Genetics; National Cancer Institute; 6120 Executive Blvd. EPS/8073; Bethesda, MD 20892. Candidates should submit applications by May 30, 2008; however, the search will continue until a qualified candidate is found. Additional information about staff and ongoing research in the Division of Cancer Epidemiology and Genetics and in the Infections and Immunoepidemiology Branch is available at http://www.dceg.cancer.gov. Prospective applicants should send e-mail inquiries to Allan Hildesheim, Ph.D., Branch Chief (hildesha@exchange.nih.gov). DHHS and NIH are Equal Opportunity Employers. ### 3) Tenure-Track Investigator Immunoepidemiologist, NCI (deadline: May 30) The new NCI Infections and Immunoepidemiology Branch (IIB) in the Division of Cancer Epidemiology and Genetics (DCEG) is recruiting for a tenure-track epidemiologist with experience and interest in the study of immunology and cancer. Research at the IIB focuses on understanding the causes and mechanisms involved in the development of tumors linked to infectious agents and in understanding the mechanisms underlying successful immune responses as they relate to cancer risk and to successful responses to vaccination. Both infectious and host immunological factors are considered in the context of human epidemiological studies. Studies undertaken by the group are often large, international and include rich biological specimen components to permit in-depth evaluation of biological processes, including immunological and inflammatory mechanisms, involved in tumor development and vaccination responses using state-of-the-art techniques. The Branch has an active set of studies aimed at evaluating the role of numerous infectious agents (including EBV, HIV, HPV, HTLV-1, and KHSV) and tumor sites (including cervical cancer, gastric cancer, Hodgkin and non-Hodgkin lymphomas, lung cancer, nasopharyngeal carcinoma, and oral/oropharyngeal cancers). The Branch also houses the 7,500 woman community-based vaccine trial in Costa Rica designed to evaluate the efficacy and impact of a new HPV-16/18 virus-like particle vaccine, and an HPV immunology laboratory that complement field activities and allows interactive evaluation of hypotheses of immunological importance within our studies. The successful candidate will receive research support from the intramural research program of NIH for conducting innovative studies aimed at elucidating inflammatory and immunological mechanisms of HPV-related or other cancers and/or vaccine responses. Applicants must have an M.D. and/or Ph.D. in epidemiology or a related field, and considerable post-doctoral experience in cancer epidemiology, molecular epidemiology, and/or tumor or vaccine immunology. A record of peer-reviewed publications in one of these fields is required. The successful candidate should have strong analytical skills, a good understanding of biological/immunological processes, and a demonstrated ability to collaborate across disciplines. Strong oral and written communication skills are an important requirement. Applications will be evaluated on demonstrated ability to lead complex epidemiologic investigations; to develop a creative, independent program of epidemiological research applicable to understanding immune determinants of successful vaccination against cancer causing infections and/or immunological determinants of HPV-related or other cancers; and to collaborate effectively in a multidisciplinary setting. Interested individuals should send a cover letter, curriculum vitae, a brief summary of research experience, accomplishments and research interests and goals, copies of three publications or preprints, and three letters of reference to: Ms. Judy Schwadron; Division of Cancer Epidemiology and Genetics; National Cancer Institute; 6120 Executive Blvd. EPS/8073; Bethesda, MD 20892. Candidates should submit applications by May 30, 2008; however, the search will continue until a qualified candidate is found. Additional information about staff and ongoing research in the Division of Cancer Epidemiology and Genetics and in the Infections and Immunoepidemiology Branch is available at http://www.dceg.cancer.gov. Prospective applicants should send e-mail inquiries to Allan Hildesheim, Ph.D., Branch Chief (hildesha@exchange.nih.gov). DHHS and NIH are Equal Opportunity Employers. ### 4) Tenure Track/Tenured Position Basic Computational Biomedical Research, NHLBI (deadline: May 31) Division of Intramural Research (DIR) of the National Heart, Lung and Blood Institute is seeking an outstanding computational scientist to initiate and direct an independent research program on the NIH campus in Bethesda and Rockville, Md. The area of expertise of the candidate is less important than his/her demonstrated ability to conduct outstanding independent research in areas within the broad interests of the DIR. The areas of expertise may include but are not limited to: computational systems biology, computational biophysics, bioinformatics, computational chemistry, computational structural biology, computational proteomics/genomics, and cellular/molecular imaging theory. Although this position is computational in nature, limited resources are also potentially available for experimental studies. Potential candidates are welcome to view the NHLBI DIR web pages (http://dir.nhlbi.nih.gov/) to review the research programs and support available within the DIR. The existing faculty is an outstanding group of internationally recognized biomedical researchers covering a wide range of basic and clinical research topics complemented by the other DIR programs within NIH. Strong research core support in optical and electron microscopy, transgenic and knockout mouse production, mouse phenotyping, proteomics, genomics, and flow cytometry/cell sorting is available to the DIR faculty. Candidates can also participate in Graduate Partners Programs (http://gpp.nih.gov/) with many academic programs around the world as a means of recruiting graduate students. The candidate must have an M.D., Ph.D., or both and have an outstanding record of research accomplishments as evidenced by publications in major peer-reviewed journals. The position can be filled as a tenure-track or tenured position, but preference will be given to senior post-doctoral fellows or faculty who are still in the early stages of their research careers. The successful candidate will be offered a competitive salary commensurate with experience and qualifications, and will be assigned ample research space, supported positions, and an operating budget. Appointees may be US citizens, resident aliens, or non-resident aliens with or eligible to obtain a valid employment authorized visa. Applications must be received by May 31, 2008. Please submit a curriculum vitae and brief statement of research interests along with three letters of reference to: Robert S. Balaban, Ph.D., Scientific Director, NHLBI; c/o Douglas Price; Administrative Officer, NHLBI; 10 Center Drive, MSC 1670; Building 10, Room 7N220; Bethesda, MD 20892-1670. DHHS and NIH are Equal Opportunity Employers. ### Senior Investigator, Tenure-Track Investigator, Staff Scientist Bioinformatics/Computational Biology Biostatistics Branch, NIEHS (deadline: open-ended) The Biostatistics Branch is seeking scientists in Bioinformatics/Computational Biology. Candidates will be considered for Senior Investigator, Tenure-Track Investigator or Staff Scientist, depending upon qualifications (unless they explicitly specify a particular type of appointment). As a Senior Investigator, the incumbent will develop and direct a strong research program including both investigator-initiated and collaborative research in the general area of bioinformatics and computational biology, particularly as related to biological networks, analysis of high-dimensional data, proteomics, comparative and functional genomics, gene expression, statistical genetics, and epigenetics. Responsibilities would also include assembling and managing a bioinformatics team to provide bioinformatics infrastructure and innovative data analysis approaches in support of intramural research aimed at understanding biological responses to environmental stressors in the context of cell biology, animal toxicology, clinical research and epidemiology. The Senior Investigator will provide leadership in bioinformatics to new staff and to existing staff, consisting of a staff scientist and tenure-track investigator. Ideal candidates will have a proven history of individual and collaborative research excellence and an international reputation in a specific area within the broad general of bioinformatics and computational biology, with strong focus on biological applications. The Tenure-Track Investigator should have a strong publication record and robust and original research plans in the general area of bioinformatics noted above. The Staff Scientist will work with the National Toxicology Program to assist in the identification of genes governing biological responses to environmental exposures, the evaluation and interpretation of biological response data from high-throughput toxicity screening assays, and the analysis of gene expression data from microarray studies. The ideal applicant will have experience in both bioinformatics and statistical genetics methodology. All applicants must possess a Ph.D. or equivalent. Salary is commensurate with experience and level of accomplishments. Applications from women and members of minority groups are particularly welcome. To apply, submit a curriculum vitae, bibliography, brief statement of research interests and arrange for three letters of recommendation to: Mr. Will Williams (DIR07-06); National Institutes of Health; National Institute of Environmental Health Sciences; P.O. Box 12233 Maildrop A2-06; 111 Alexander Drive, Room A235; Research Triangle Park, NC 27709. Email: dir-appls@niehs.nih.gov. Positions open until filled. HHS and NIH are Equal Opportunity Employers. Link to all NIH Jobs http://www.jobs.nih.gov/ Links to Fellowships http://www.training.nih.gov/